Welcome to the home of network biology at Washington University in St. Louis

Our Mission: Model, predict and design functions of biological systems that result from integration of signals and responses of biomolecular and cellular networks


CBSE researchers aid in the battle against Ebola

Work by Anu Mittal, post doc in the Pappu lab, has contributed towards a groundbreaking study by the Amarasinghe lab at Washington University School of Medicine on the mechanism by which Ebola blocks the immune system. For more information, please see the press release .




CBSE Scholars

Congratulations to doctoral students Chao Li, Tom Ronan, and Kiersten Ruff, who have been named the 2014-2015 CBSE scholars. As CBSE scholars, each is expected to present their thesis proposal before the end of 2014, as well as publish a first author paper by June 2015 and present their work in the spring CBSE seminar series.




Kathrin Andrich receives travel award

Kathrin Andrich, a graduate student in the Bieschke lab, won a travel award to the XIVth International Symposium of Amyloidosis to present here doctoral research




Biophysical Society student awards

Kiersten Ruff and Alex Holehouse, graduate students in the Pappu lab, were two of the winners of the SRAA poster competition at the 2014 Biophysical Society meeting. They won for their work on polyglutamine aggregation and the mechanism of denaturant-peptide interactions, respectively.

Fall 2014 CBSE seminar series:

Noon (12 PM)
Brauer Hall, Room 12 ( lower level lecture hall )
Download Flyer


Sept 9th: Vijay Pande, Stanford University

Oct 7th: Greg Bowman, WUSM Biophysics

Oct 28th: Susan Marqusee, UC Berkeley

Nov 11th: Steven Finkbeiner, UCSF & Gladstone Institute

Dec 2nd: Vitaly Klyachko, WUSTL BME

Dec 9th: Nathan Price, UCSD



Ruff KM, Khan SJ, Pappu RV (2014)

A coarse-grained model for polyglutamine aggregation modulated by amphipathic flanking sequences. Biophysical Journal, In press


Xu Q, Sawatzky A, Roessl E, Anastasio MA, Schirra CO (2014)

Sparsity-regularized image reconstruction of decomposed K-edge data in spectral CT. Phys. Med. Biol., In press


Reese TA, Wakeman BS, Choi HS, Hufford MM, Huang SC, Zhang X, Buck MD, Jezewski A, Kambal A, Liu CY, Goel G, Murray PJ, Xavier RJ, Kaplan MH, Renne R, Speck SH, Artyomov MN, Pearce EJ, Virgin HW (2014)

Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter. Science, Vol. 345 no. 6196 pp. 573-577.


Xu W, Edwards MR, Borek DM, Feagins AR, Mittal A, Alinger JB, Berry KN, Yen B, Hamilton J, Brett TJ, Pappu RV, Leung DW, Basler CF, Amarasinghe GK (2014)

Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1. Cell Host & Microbe, 16, pp. 187-200.


Predeus A, Gopalakrishnan S, Huang Y, Tung J, Feeney AJ, Oltz EM, Artyomov MN. (2014)

Chromatin Profiling Reveals Novel Enhancers in Immunoglobulin Heavy and Light Chain Loci. J Immunol , 1;129(3) pp. 1064-1070


Cho Y, Sloutsky R, Naegle KM, Cavalli V. (2013)

Injury-Induced HDAC5 Nuclear Export Is Essential for Axon Regeneration. Cell, 155 pp. 894 – 908


Sloutsky R, Jimenez N, Swamidass SJ, Naegle KM. (2013)

Accounting for noise when clustering biological data. Brief. Bioinform. 14, pp 423 – 436