Welcome to the home of network biology at Washington University in St. Louis

Our Mission: Model, predict and design functions of biological systems that result from integration of signals and responses of biomolecular and cellular networks.

CBSE Evenings

Starting in October, the CBSE will begin its monthly Monday evening series of talks.The theme for this year's series is Machine Learning Theory and Applications in Biology & Biomedical Sciences.

This informal series will be accompanied by pizza and beer. The schedule thus far is as follows:

The seminars will be held in Brauer 3015 at 5:30 pm, and are open to all.

2015-2016 CBSE Scholars

The new CBSE scholarships for 2015-2016 have been announced! The CBSE scholarships reflect the academic excellence of doctoral students in the center. This years recipients are listed below;

Congratulations to all!

Raman lab in Nature Communications

Work by professor Barani Raman exploring how locust brains process neural stimuli has been published in Nature Communications. This work, spearheaded by co-first authors Debajit Saha and Chao Li (CBSE scholar), sets a paradigm for tracking neural responses and sheds light on how neurons process and filter complex information. The work has been made open access through generous support from the CBSE.

For more information, see the Washington University press release, or read the paper now online.

Rohit Pappu Named Endowed Professor

Rohit Pappu was named as the Edwin. H. Murty endowed Professor of Engineering, with an installation ceremony held on March 2nd 2015. He and his lab members have developed and used novel combinations of polymer physics theories, molecular simulations and biophysical experiments to provide definitive descriptors that relate information contained in these intrinsically disordered proteins sequences to their conformational characteristics and aggregation mechanisms.

Artyomov lab on cover of Immunity

Work by professor Maxim Artyomov examining metabolic determinants of macrophage polarization has been published in Immunity. Using a systems biology approach to analyze cellular metabolic status, lead author Jha and colleagues identified the key metabolites and metabolic processes which are required for specific states of macrophage polarization. For more information, the paper is available here.

Biophysical Society Student Award

Alex Holehouse, a graduate student in the Pappu Lab, was one of the winners of the Biophysical Society's Student Research Achievement Award (SRAA). Alex won for his work on developing tools to understand sequence-conformation relationships in intrinsically disordered proteins.

Kathrin Andrich wins travel award

Kathrin Andrich, a graduate student in the Bieschke lab, won a travel award to the 59th Annual Biophysical Society Meeting in Baltimore, MD.

CBSE researchers aid in the battle against Ebola

Work by Anu Mittal, post doc in the Pappu lab, has contributed towards a groundbreaking study by the Amarasinghe lab at Washington University School of Medicine on the mechanism by which Ebola blocks the immune system. For more information, please see the press release .

CBSE Scholars 2014-2015

Congratulations to doctoral students Chao Li, Tom Ronan, and Kiersten Ruff, who have been named the 2014-2015 CBSE scholars. As CBSE scholars, each is expected to present their thesis proposal before the end of 2014, as well as publish a first author paper by June 2015 and present their work in the spring CBSE seminar series.

Fall 2015 CBSE seminar series:

Noon (12 PM)
Brauer Hall, Room 3015 ( upper level seminar room )

Sep 22nd: David Savage, UC Berkeley

Oct 20th: Clifford Brangwynne, Princeton University

Oct 27th: Arjun Raj, University of Pennsylvania

Nov 3rd: Nathan Baker, Pacific Northwest National Labs

Nov 17th: Julie Forman-Kay, University of Toronto

C.P. Brangwynne, P.S. Tompa, R.V. Pappu (2015)

Polymer Physics of Intracellular Phase Transitions - Nature Physics, In Press

Saha, D., Li, C., Peterson, S., Padovano, W., Katta, N., & Raman, B (2015)

Behavioural correlates of combinatorial versus temporal features of odour codes - Nature Communications, 6, 6953

Jha, A. K., Huang, S. C.-C., Sergushichev, A., ... Artyomov, M. N. (2015)

Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization - Immunity, 42(3), 419 - 430

Andrich, K., & Bieschke, J. (2015)

The Effect of (-)-Epigallo-catechin-(3)-gallate on Amyloidogenic Proteins Suggests a Common Mechanism - Adv. in Exp. Med. and Biol., 863, 139 - 161

Naegle, K., Gough, N. R., & Yaffe, M. B. (2015)

Criteria for biological reproducibility: what does “n” mean? Science Signaling, 8(371), fs7.863

Guan, H., Xu, Q., Garson, A. B., 3rd, & Anastasio, M. A. (2015)

Boundary-enhancement in propagation-based x-ray phase-contrast tomosynthesis improves depth position characterization - Phys. in Med. and Biol., 60(8), N151 - 65

Hughes TB, Miller GP, and Swamidass SJ (2015)

Site of Reactivity Models Predict Molecular Reactivity of Diverse Chemicals with Glutathione - Chem. Res. Toxicol., 28(4), 797–809

Holehouse AS, Garai K, Lyle N, Vitalis A, Pappu RV (2015)

Quantitative assessments of the distinct contributions of polypeptide backbone amides versus sidechain groups to chain expansion via chemical denaturation. JACS, 137, 2984 - 2995

Zaretzki J, Browning M, Hughes TB and Swamidass SJ (2015)

Extending P450 Site-of-Metabolism Models with Region-Resolution Data. Bioinformatics, 31(12), 1966 - 1973

Matlock MK, Holehouse AS, Naegle KM (2015)

ProteomeScout: a repository and analysis resource for post-translational modifications and proteins - Nucleic Acids Research, 43 (D1), D521 - D530

Baldridge, M. T., Nice, T. J., McCune, ... Artyomov, M. N. Virgin, H. W. (2015)

Commensal microbes and interferon-λ determine persistence of enteric murine norovirus infection - Science, 347(6219), 266–269

Silva, J. R., Cooper, P., & Nichols, C. G. (2014)

Modeling K,ATP--dependent excitability in pancreatic islets - Biophysical Journal, 107(9), 2016 - 2026

Ruff KM, Khan SJ, Pappu RV (2014)

A coarse-grained model for polyglutamine aggregation modulated by amphipathic flanking sequences - Biophysical Journal, 107(5), 1226 - 1235.