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Our Mission: Model, predict and design functions of biological systems that result from integration of signals and responses of biomolecular and cellular networks


CBSE researchers aid in the battle against Ebola

Work by Anu Mittal, post doc in the Pappu lab, has contributed towards a groundbreaking study by the Amarasinghe lab at Washington University School of Medicine on the mechanism by which Ebola blocks the immune system. For more information, please see the press release .




CBSE Scholars

Congratulations to doctoral students Chao Li, Tom Ronan, and Kiersten Ruff, who have been named the 2014-2015 CBSE scholars. As CBSE scholars, each is expected to present their thesis proposal before the end of 2014, as well as publish a first author paper by June 2015 and present their work in the spring CBSE seminar series.




Kathrin Andrich receives travel award

Kathrin Andrich, a graduate student in the Bieschke lab, won a travel award to the XIVth International Symposium of Amyloidosis to present here doctoral research.




Biophysical Society student awards

Kiersten Ruff and Alex Holehouse, graduate students in the Pappu lab, were two of the winners of the SRAA poster competition at the 2014 Biophysical Society meeting. They won for their work on polyglutamine aggregation and the mechanism of denaturant-peptide interactions, respectively.

Fall 2014 CBSE seminar series:

Noon (12 PM)
Brauer Hall, Room 3015 ( upper level seminar room )


Jan 20th: Doug Barrick, Johns Hopkins University

Jan 27th: Mona Singh, Princeton University [Cancelled due to bad weather on the East coast]

Feb 17th: Gautam Dantas, WUSM

Feb 24th: Jason Locasale, Cornell University

March 3rd: Jeff Saucerman, University of Virginia

April 7th: Stephen Michnick, University of Montreal

April 28th: Marina Ramirez-Alvarado, Mayo Clinic

May 12th: Roy Parker, University of Colorado Boulder



Matlock MK, Holehouse AS, Naegle KM (2014)

ProteomeScout: a repository and analysis resource for post-translational modifications and proteins. Nucleic Acids Research, In press



Ruff KM, Khan SJ, Pappu RV (2014)

A coarse-grained model for polyglutamine aggregation modulated by amphipathic flanking sequences. Biophysical Journal, Vol. 107 no. 5 pp. 1226-1235.


Xu Q, Sawatzky A, Roessl E, Anastasio MA, Schirra CO (2014)

Sparsity-regularized image reconstruction of decomposed K-edge data in spectral CT. Phys. Med. Biol., Vol. 21 no. 10 pp. N65-79


Reese TA, Wakeman BS, Choi HS, Hufford MM, Huang SC, Zhang X, Buck MD, Jezewski A, Kambal A, Liu CY, Goel G, Murray PJ, Xavier RJ, Kaplan MH, Renne R, Speck SH, Artyomov MN, Pearce EJ, Virgin HW (2014)

Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter. Science, Vol. 345 no. 6196 pp. 573-577.


Xu W, Edwards MR, Borek DM, Feagins AR, Mittal A, Alinger JB, Berry KN, Yen B, Hamilton J, Brett TJ, Pappu RV, Leung DW, Basler CF, Amarasinghe GK (2014)

Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1. Cell Host & Microbe, 16, pp. 187-200.


Predeus A, Gopalakrishnan S, Huang Y, Tung J, Feeney AJ, Oltz EM, Artyomov MN. (2014)

Chromatin Profiling Reveals Novel Enhancers in Immunoglobulin Heavy and Light Chain Loci. J Immunol , 1;129(3) pp. 1064-1070


Cho Y, Sloutsky R, Naegle KM, Cavalli V. (2013)

Injury-Induced HDAC5 Nuclear Export Is Essential for Axon Regeneration. Cell, 155 pp. 894 – 908


Sloutsky R, Jimenez N, Swamidass SJ, Naegle KM. (2013)

Accounting for noise when clustering biological data. Brief. Bioinform. 14, pp 423 – 436