Welcome to the home of network biology at Washington University in St. Louis

Our Mission: Model, predict and design functions of biological systems that result from integration of signals and responses of biomolecular and cellular networks

Rohit Pappu Named Endowed Professor

Rohit Pappu was named as the Edwin. H. Murty endowed Professor of Engineering, with an installation ceremony held on March 2nd 2015. He and his lab members have developed and used novel combinations of polymer physics theories, molecular simulations and biophysical experiments to provide definitive descriptors that relate information contained in these intrinsically disordered proteins sequences to their conformational characteristics and aggregation mechanisms.

Biophysical Society Student Award

Alex Holehouse, a graduate student in the Pappu Lab, was one of the winners of the Biophysical Society's Student Research Achievement Award (SRAA). Alex won for his work on developing tools to understand sequence-conformation relationships in intrinsically disordered proteins.

Kathrin Andrich wins travel award

Kathrin Andrich, a graduate student in the Bieschke lab, won a travel award to the 59th Annual Biophysical Society Meeting in Baltimore, MD.

CBSE researchers aid in the battle against Ebola

Work by Anu Mittal, post doc in the Pappu lab, has contributed towards a groundbreaking study by the Amarasinghe lab at Washington University School of Medicine on the mechanism by which Ebola blocks the immune system. For more information, please see the press release .

CBSE Scholars

Congratulations to doctoral students Chao Li, Tom Ronan, and Kiersten Ruff, who have been named the 2014-2015 CBSE scholars. As CBSE scholars, each is expected to present their thesis proposal before the end of 2014, as well as publish a first author paper by June 2015 and present their work in the spring CBSE seminar series.

Kathrin Andrich wins travel award

Kathrin Andrich, a graduate student in the Bieschke lab, won a travel award to the XIVth International Symposium of Amyloidosis to present here doctoral research.

Fall 2014 CBSE seminar series:

Noon (12 PM)
Brauer Hall, Room 3015 ( upper level seminar room )

Jan 20th: Doug Barrick, Johns Hopkins University

Jan 27th: Mona Singh, Princeton University [Cancelled due to bad weather on the East coast]

Feb 17th: Gautam Dantas, WUSM

Feb 24th: Jason Locasale, Cornell University

March 3rd: Jeff Saucerman, University of Virginia

April 7th: Stephen Michnick, University of Montreal

April 28th: Marina Ramirez-Alvarado, Mayo Clinic

May 12th: Roy Parker, University of Colorado Boulder [In Brauer 012 (lower level)]

Hughes TB, Miller GP, and Swamidass SJ (2015)

Site of Reactivity Models Predict Molecular Reactivity of Diverse Chemicals with Glutathione. Chem. Res. Toxicol., In press

Holehouse AS, Garai K, Lyle N, Vitalis A, Pappu RV (2015)

Quantitative assessments of the distinct contributions of polypeptide backbone amides versus sidechain groups to chain expansion via chemical denaturation. JACS, 137: 2984-2995

Zaretzki J, Browning M, Hughes TB and Swamidass SJ (2015)

Extending P450 Site-of-Metabolism Models with Region-Resolution Data. Bioinformatics, In press

Matlock MK, Holehouse AS, Naegle KM (2015)

ProteomeScout: a repository and analysis resource for post-translational modifications and proteins. Nucleic Acids Research, 43 (D1) , D521-D530

Ruff KM, Khan SJ, Pappu RV (2014)

A coarse-grained model for polyglutamine aggregation modulated by amphipathic flanking sequences. Biophysical Journal, Vol. 107 no. 5 pp. 1226-1235.

Xu Q, Sawatzky A, Roessl E, Anastasio MA, Schirra CO (2014)

Sparsity-regularized image reconstruction of decomposed K-edge data in spectral CT. Phys. Med. Biol., Vol. 21 no. 10 pp. N65-79

Reese TA, Wakeman BS, Choi HS, Hufford MM, Huang SC, Zhang X, Buck MD, Jezewski A, Kambal A, Liu CY, Goel G, Murray PJ, Xavier RJ, Kaplan MH, Renne R, Speck SH, Artyomov MN, Pearce EJ, Virgin HW (2014)

Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter. Science, Vol. 345 no. 6196 pp. 573-577.

Xu W, Edwards MR, Borek DM, Feagins AR, Mittal A, Alinger JB, Berry KN, Yen B, Hamilton J, Brett TJ, Pappu RV, Leung DW, Basler CF, Amarasinghe GK (2014)

Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1. Cell Host & Microbe, 16, pp. 187-200.

Predeus A, Gopalakrishnan S, Huang Y, Tung J, Feeney AJ, Oltz EM, Artyomov MN. (2014)

Chromatin Profiling Reveals Novel Enhancers in Immunoglobulin Heavy and Light Chain Loci. J Immunol , 1;129(3) pp. 1064-1070

Cho Y, Sloutsky R, Naegle KM, Cavalli V. (2013)

Injury-Induced HDAC5 Nuclear Export Is Essential for Axon Regeneration. Cell, 155 pp. 894 – 908

Sloutsky R, Jimenez N, Swamidass SJ, Naegle KM. (2013)

Accounting for noise when clustering biological data. Brief. Bioinform. 14, pp 423 – 436